GENERAL
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"Just like we didn't envision the powers of PCs thirty years ago, we may not be seeing all the uses of cord blood yet." |
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LeeAnn Jensen, M.D.
Immunologist National Institutes of Health
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"...Some might argue that there is little to lose (except money) by freezing one's cord-blood cells. If they are needed, fine; if not, even better." |
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Robert Peter Gale, M.D., Ph.D.
Executive Committee Past Chair International Bone Marrow Transplant Registry (IBMTR) |
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"I strongly recommend that all expectant parents ask their doctor about the lifesaving potential of cord blood... Today, cord blood is being used to treat such life-threatening diseases as leukemia and other cancers, as well as certain blood and immune disorders that formerly necessitated a bone marrow transplant." |
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Dr. Marianne Neifert, Pediatrician
Baby Talk Magazine, October 1997 |
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"Someday, collecting placental-umbilical cord blood may be as routine as it is unusual now...[It's] an opportunity to have the blood kept after delivery as biological insurance for the child." |
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Journal of the National Cancer Institute, February 1, 1995 |
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BENEFITS OF CORD BLOOD
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"Particular properties of lymphoid progenitors in cord blood might favor a greater thymic contribution and prompt a more durable long-term reconstitution [compared to stem cells from bone marrow]." |
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Eliane Gluckman, Kimmo Talvensaari, Emmanuel Clave, et al.
Blood, February 15, 2002 |
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"Recipients of cord-blood transplants from HLA-identical siblings have a lower incidence rate of acute and chronic GVHD than recipients of bone marrow transplants from HLA-identical siblings." |
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Vanderson Rocha, M.D., John E. Wagner, Jr. , M.D., Eliane Gluckman, M.D., et. Al.
New England Journal of Medicine, June 22, 2000 |
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"Early data indicate that [cord blood] stem cells [are] associated with both a higher rate of engraftment and lower rate of significant graft-versus-host disease (GvHD) than is marrow from traditional donors." |
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Eddleman, K.
Contemporary OB/GYN, July 1998 |
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"The ultimate goal is for all usable umbilical cord blood to be banked in a national cord blood [bank] similar to the National Bone Marrow Donor Program or saved for an individual's or family's own potential use. The latter may prove especially significant for those with a family history of leukemia or cancer or for minority ethnic patients." |
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Nursing Spectrum, February 24, 1997 |
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"About 40% of the desperately ill patients who need bone marrow transplants never get them, because a donor who is an exact match can't be found through family connections or by the National Marrow Donor Program. Two reports in the July 18, 1996, New England Journal of Medicine strongly suggest that many of these patients could be helped by transplants of stem cells from placental [cord] blood, which is routinely discarded after babies are delivered." |
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"Top Ten Medical Advances of 1996," The Harvard Health Letter, March 1997, Vol. 22, No. 5 |
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CORD BLOOD AND ADULT USE
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"Umbilical-cord blood from unrelated donors can restore hematopoiesis in adults who receive myeloablative therapy and is associated with acceptable rates of severe acute and chronic GVHD." |
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Mary J. Laughlin, M.D., Juliet Barker, M.D., Barbara Bambach, M.D., et. Al.
New England Journal of Medicine, June 14, 2001 |
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FUTURE USE
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"A really exciting area that's just now in the basic science lab, is the area where stem cells ...can be used for going over to muscle cells like your heart muscle if you had a heart attack...or brain cells if you had Parkinson's Disease...Hopefully, in 20 or 30 or 40 years...these might be potential applications for stem cells including umbilical cord blood stem cells." |
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Dr. Stanton Goldman, Pediatric Hematologist Oncologist and stem cell transplant Physician, Medical City, Dallas, Texas |
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"Through cultivation of stem cells extracted from the cord blood, patients with spinal injuries have a great chance of having their damaged nervous system repaired, helping them to rise on their feet again." |
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Chiang Yung-hsiao, M.D., Ph.D., Chairman of Neurosurgery, Tri-Service General Hospital, Tapei, Taiwan |
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"[Cord blood stem cells] might be suitable for transplantation in neurodegenerative diseases, gene delivery to the central nervous system, and repair of brain and spinal cord injuries." |
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Juan R. Sanchez-Ramos, Shijie Song, Siddharth G. Kamath, et. Al.
Experimental Neurology, 171, 2001
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"The promise of stem cells in the prevention and treatment of many diseases, including cancer, is so immense that it would be almost irresponsible for research on this technology to be marginalized... [W]e should also never lose sight of the tremendous life-saving possibilities of this technology." |
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Statement of Dr. Joseph Bailes, President Elect of the American Society of Clinical Oncology before the House Committee on Appropriations, Subcommittee on Labor, Health and Human Services, and Education, April 21, 1999
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"Hematopoetic stem cells, i.e., cells capable of giving rise to the entire spectrum of mature hematopoetic and lymphoid cells, are the target of gene therapy for a variety of hematologic and immunologic disorders...The umbilical cord of neonates provides a unique alternative to bone marrow as a source of hematopoetic stem cells." |
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Kohn, D.B, Parkman, R.
The FASEB Journal, July 1997 |
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INFANT USE OF OWN STEM CELLS
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"Our study supports the recommendation of early intensification with autologous or allogeneic stem cell therapy rescue for infants with acute leukemia in CR1." |
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Fernando Marco, Encarna Bureo, Juan J. Ortega, et. al
Journal of Clinical Oncology, September 15, 2000 |
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"As a result of numerous preclinical and clinical studies supporting the feasibility and efficacy of umbilical cord blood transplantation, there has been a growing interest in the large-scale collection of umbilical cord blood stem cells for future self-use by the infant....This service should be made available to individuals who feel a greater security knowing that they have stored their child's stem cells for future use if necessary."
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Wagner, J.
The Journal of Hematotherapy, February 1997, Vol. 6, No. 1 |
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"Autologous cord blood collections [collection for one's own use] could also be used as insurance against future illness requiring pluripotent stem cell support or as targets for gene therapy (the genetically altered stem cells could then be infused into the patient)." |
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Jay Feingold, M.D., Ph.D. Director, Pediatric Bone Marrow Transplant Program,
University of Connecticut, New Developments in Transplantation Medicine, Summer 1996, Vol. 3, No. 1. |
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